Dianabol is a relatively strong estrogenic anabolic steroid due to the moderate level of aromatase activity it carries. While its aromatase activity is only moderate, this conversion actually leads Methandrostenolone to be converted to methylestradiol rather than estradiol, which is far more powerful than estradiol. This can make side effects like gynecomastia and water retention very possible with this steroid; in fact, they can appear seemingly overnight. Heavy water retention can also promote high blood pressure, which Dianabol is notorious for causing. Such effects can be controlled, and when it comes to high blood pressure this is something you’ll need to put some effort into ensuring does not become a problem.
In order to combat the estrogenic side effects of Dianabol, anti- estrogens are commonly recommended when supplementing with this steroid. You have two choices in anti-estrogens, Selective Estrogen Receptor Modulators (SERM’s) like Nolvadex ( Tamoxifen Citrate ) and Aromatase Inhibitors (AI’s) like Femara ( Letrozole ). SERM’s can be enough for some men and should be your first choice if they can get the job done. However, AI’s will be far more effective as they will directly inhibit aromatization and reduce serum estrogen levels. Unfortunately, AI’s can negatively affect cholesterol, as can Dianabol, and when conjoined this can prove potentially problematic. If an AI is used cholesterol management will be a priority, and it will be possible. However, SERM’s, while not always as effective will actually promote healthier cholesterol levels due to their estrogenic like activity in the liver.
While it may sound overly simplistic, one of the best things you can do to combat Dianabol side-effects is to live a healthy lifestyle. This shouldn’t come as a surprise, after all, to maintain a proper blood pressure and healthy cholesterol levels you must live a healthy lifestyle. For this reason, you are encouraged to keep an eye on your diet; stay away from foods that are junky, and be sure to get in plenty of healthy fats, as such foods will greatly serve you in a tremendous fashion. Foods that contain omega-3 fatty acids will serve you well. Further, abstaining from alcohol is a great idea, as is any other activity that might bring about undue stress to the body. If you can do these things, keep your doses moderate and supplement for proper periods of time, almost all of you will be fine. We say almost all for one simple reason, we are all unique individuals, and there may be some who even when responsible have problems. Look at it this way, some of us can drink milk, while others can’t and such is the nature of life. Even so, through responsible use, Dianabol side-effects as you can see are very easy to control.
After the Kefauver Harris Amendment was passed in 1962, the . FDA began the DESI review process to ensure the safety and efficacy of drugs approved under the more lenient pre-1962 standards, including Dianabol.  In 1965, the FDA pressured CIBA to further document its legitimate medical uses, and re-approved the drug for treating post-menopausal osteoporosis and pituitary-deficient dwarfism .  After CIBA's patent exclusivity period lapsed, other manufacturers began to market generic metandienone in the .