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Because the ultimate goal of a steroid cycle is to increase strength and muscle size, the associated spike in estrogen which accompanies steroids such as Testosterone is considered undesirable. In order to disassociate the two effects, two classes of drug are used. Medications such as Nolvadex or Clomid target the estrogen receptors. They make it more difficult for the estrogen to exert it’s influence within the body thus allowing the testosterone to act more freely. The second class is aromatase inhibitors such as Femara. They target the aromatase enzyme itself in order to prevent the production of estrogen in the first place. Sometimes, it’s not always clear which option you should go with or even what the differences are between the two. Lets clear that up a little.

For average gymrats who never plan on stepping upon a bodybuilding state, Nandrolone may still be a perfect drug for you! You can enjoy its mass building effects in the off-season, and it’s effects upon muscle hardening when caloric restriction takes place. Remember that 99% of the people in a gym will never step on a competitive stage, so 99% of them don’t need to worry about drug testing. Likewise, if you plan on competing 2-3 years down the road once you’ve gained a great deal more mass and definition, then Nandrolone might be perfect for you. Just don’t play with the drug if you plan to be tested this year!

Note that in androgen-responsive target tissues such as the skin, scalp, and prostate, the relative androgenicity of nandrolone is reduced by its reduction to dihydronandrolone (DHN). 438 439 The 5-alpha reductase enzyme is responsible for this metabolism of nandrolone. The concurrent use of a 5-alpha reductase inhibitor such as finasteride or dutasteride will interfere with site-specific reduction of nandrolone action, considerably increasing the tendency of nandrolone to produce androgenic side effects. Reductase inhibitors should be avoided with nandrolone if low androgenicity is desired.

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