Masteron will significantly suppress natural testosterone production making exogenous testosterone therapy important when using this steroid. Failure to include exogenous testosterone will lead most men to a low testosterone condition, which not only comes with numerous possible symptoms but is also extremely unhealthy.
As most will use Masteron in a cutting cycle, it’s very common not to want to use a lot of testosterone due to the high levels of estrogenic activity it can provide. If this is the case, you will find a low dose of 100-200mg per week of testosterone to be enough to combat suppression and give you the needed testosterone.
Once Masteron is discontinued and all exogenous steroidal hormones have cleared your system, natural testosterone production will begin again. Prior levels will not return to normal over night, this will take several months. Due to the slow recovery, Post Cycle Therapy (PCT) plans are often recommended. This will speed up the recovery greatly; however, it won’t bring your levels back to their peak, this will still take time. A PCT plan will ensure you have enough testosterone for proper bodily function while your levels continue to naturally rise and significantly cut down on the total recovery time. This natural recovery does assume no prior low testosterone condition existed. It also assumes no damage was done to the Hypothalamic-Pituitary-Testicular-Axis (HPTA) through improper supplementation practices.
First and foremost, it is important to mention that there is no risk what so ever of any Estrogen related side effects from Masteron Enanthate alone. As mentioned previously, Masteron Enanthate not only avoids aromatization into Estrogen completely, but it even acts as an anti-Estrogen in many cases. Therefore, the typical estrogenic side effects that result from the use of aromatizable anabolic steroids is avoided. This includes: bloating, water retention, blood pressure increases (as a result of water retention), acne, and gynecomastia. Because of Masteron’s anti-estrogenic properties, it can actually help prevent or mitigate these side effects if they are occurring from other anabolic steroids that do aromatize.
It was in late 2005 that the status of methasterone, in addition to that of four other designer steroids, as an AAS was brought to public awareness by an article published in the Washington Post .  Don Catlin of the UCLA Olympic Laboratory, who conducted the studies, noted methasterone’s similarity to drostanolone. A warning by the FDA was issued soon after to the general public as well as to the distributor, Designer Supplements LLC, for the marketing of this compound.  Methasterone was subsequently added to the World Anti-Doping Agency (WADA) list of prohibited substances in sport.  Despite all of this, methasterone has resurfaced within the supplement industry on several occasions since its banning by WADA.