The common side effects of oxymetholone include depression, lethargy, headache, swelling, rapid weight gain, priapism , changes in skin color, urination problems, nausea , vomiting , stomach pain (if taken on an empty stomach), loss of appetite, jaundice , breast swelling in men, feeling restless or excited, insomnia , and diarrhea .  In women, side effects also include acne , changes in menstrual periods , deepened voice, hair growth on the chin or chest, male pattern baldness , enlarged clitoris , and changes in sex drive .  Because of its 17α-alkylated structure, oxymetholone is highly hepatotoxic . Long term use of the drug can cause a variety of serious ailments, including hepatitis , liver cancer , and cirrhosis ; therefore periodic liver function tests are recommended for those taking oxymetholone. 
In December 2015 the International Cricket Council (ICC) has reported an anti-doping rule violation against the Pakistan cricket player Yasir Shah after his sample tested positive for the prohibited substance Chlorthalidone. After notification a provisional suspension was ordered and the Athlete filed a statement in his defence. The Athlete gave a prompt admission and stated that the violation occurred without intention to enhance his sport performance or to mask the use of any other prohibited substance. He explained that both he and his wife suffered from high blood pressure and used different prescribed medication. In the morning before the match he was struck by hight blood pressure and by mistake under urgent and stressful circumstance he used his wife medication that contains Atenolol and Chlortalidone. The Athlete produced relevant medical information and showed the similarities to the blister packs containing the medications for him and his wife. Also he mentioned his medical condition and the use of his wife medication on the Doping Control Form. The ICC accepts the Athlete’s explanation how the substance entered his system under extreme and unique circumstances and concludes that he not intentionally acted with No Significant Fault or Negligence. Therefore the ICC decides on 7 February 2016 to impose a 3 month period of ineligibility on the Athlete starting on the date of the provisional suspension, . on 27 December 2016.