A very typical case of severe cholestasis due to anabolic steroid use. Because the steroids were being used without medical supervision, the dose and actual duration of use of each preparation was unclear, but cholestasis usually arises within 4 to 12 weeks of starting a C-17 alkylated androgenic steroid. The jaundice can be severe and prolonged and accompanied by severe pruritus and marked weight loss. The serum enzymes are typically minimally elevated except for a short period immediately after stopping therapy. The pattern of enzyme elevations can be hepatocellular, cholestatic or mixed. Liver biopsy shows a “bland” cholestasis with minimal inflammation and hepatocellular necrosis. Ma Huang has also been implicated in cases of drug induced liver injury, but is associated with an acute hepatocellular pattern of injury.
Methandienone is an anabolic steroid banned from use by FDA under controlled substances act. Dianabol has been very popular in bodybuilders until its ban to increase strength and volume of their muscles. Dianabol acts strongly on androgen receptors and exerts its effects by protein synthesis and glycogen breakdown to increase muscle mass in short space of time. Dianabol produces estrogen as end product so water retention is also one of the contributors towards weight gain and increased volume. Dianabol effective dose is15-50 mg/day in men and its active life is 6-8 hours. Dianabol is excreted through kidneys and detection time in urine is 5-6 weeks. Until the ban Dianabol has been used as tonic by bodybuilders. Probably, Dianabol is effective in treatment of senile postmenopausal osteoporosis. Dianabol was also recommended in those individuals who are suffering from condition called pituitary deficient dwarfism. Dianabol was also used in those individuals who have weakened bones and always complain for exhaustion after small running and prolong walking. Still, Dianabol is prepared in large quantity in those countries where drugs regulations are weak and is used in human as well as in veterinary patients of the conditions described above.
The easiest way to purchase this steroid is via sites that sell nutritional and sports supplements. However, it is advisable to carry out thorough background research on the commercially available brands first. This will enable you to avoid fake steroids that can cause serious health complications or death as well as select a product that suits your needs. At the same time, make sure the brand you select complies with the relevant manufacturing best practices. A good example is compliance with the FDA’s Current Good Manufacturing Practices (CGMPs).