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- Prostate Enlargement: as this is the most concerning side effect of Proviron, it will be the preventive measure you'll want to pay the closest attention to. In-order to prevent prostate enlargement, the most important thing you'll do is to keep an eye on it, and this means having your prostate checked on a regular basis. Further, you must supplement with responsible doses and do not supplement indefinitely even with responsible doses as the DHT buildup will be too great of a risk. If you do these things, assuming your prostate is healthy and you are not abusing other DHT compounds, you should be fine. Even so, if for any reason enlargement occurs, you could have some underlying issue, this is where you'll find Finasteride to be truly useful. Finasteride has been shown to greatly improve prostate enlargement; in-fact, in many cases, 6 months of Finasteride therapy has often been shown to be enough to remedy enlargement.